Toyocerin® has demonstrated numerous beneficial effects when administered in poultry species. Several factors stress these animals when growing, which is reflected in an imbalanced gut flora that opens the opportunity for potential pathogens to attack them. In this regard, Toyocerin® administration improves the ratio Lactobacilli: Enterobacteria by a direct effect inhibiting the growth of gram negative bacteria (mainly E. coli and Salmonella). Also, Clostridia growth is inhibited. Moreover a higher gut surface and a higher number of goblet cells is observed. Response against vaccination (IB, IBV, Newcastle) is higher in chicken fed Toyocerin® showing its potential effect as a booster of the immune system.
The use of Toyocerin® in this category has demonstrated several effects in the improvement of gut health, the immune system and overall health and performance of animals. In this regard, several studies have demonstrated a clear reduction of some potential pathogenic bacteria such as E. coli and Salmonella and an increase in lactic acid bacteria. Moreover, an earlier development of the piglet immune system as well as better response of vaccines has been validated. In sows, the better gut health is reflected in higher performances, showing a higher number of piglets born and weaned, lower nonproductive days and body weight loss as well as a better quality in milk and contents of immunoglobulins in colostrum.
The efficacy of Toyocerin® in cattle has been demonstrated by Rubinum S.A. in many trials. The use of Toyocerin® in feed results in an optimal gastrointestinal microbiota and intestinal immune response which leads to a better animal growth. A modification in short chain fatty acid production in rumen and gut and an increase on the small intestine surface are the most usual effects observed when the spores of B. toyoi are administered to ruminants.
The main effects of Toyocerin® are related to the stabilization of the gut microflora by improving the intestinal health of the animals. In this regard, a clear effect on Clostridia is observed. In conjunction with the improvement in animal health, Toyocerin® improves performance parameters of rabbits and does. Some examples of these positive results are the increase of litter size and weight at the end of the lactation period or the reduction of the mortality incidence in the fattening period of the animals. Finally it should be pointed out that the use of Toyocerin® in the feed is authorized with the coccidiostats that can be used in rabbit feed.
Toyocerin® has demonstrated beneficial effects when administered to fish, promoting growth and increasing the homogeneity of specimens. Different trials with eels, trout, prawns and yellow tail have provided these results. Although the mode of action is still not fully known, there is a positive effect on the organization of the intestinal mucosa, increasing the villous height and optimizing nutrient absorption that can be behind gut and performance optimization.